Table 2 ∣.
Top diseases and functions associated with changes in kidney transcriptional profile following cisplatin administration. Top diseases and functions (P < 0.001) identified from a general (non–organ specific) database for 1689 transcripts identified by ANOVA. Significance was calculated from the p-score (p-score = −log [P value]) and focus molecules are the number of molecules that appear in network and in the dataset
| Top Diseases and Functions |
p-score | p-value | Focus Molecules |
Molecules in Network |
|---|---|---|---|---|
| Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism | 12 | 1E-12 | 16 | AADAC,ABCG2,ACSS1,ALDH1A1,CDC42BPA,DPEP1,EIF3A,EMILIN1,FAM151A,IL17RB,MID1,NAPSA,Nrg1,PKD1,POU2F1,TTR,VWF |
| Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function | 9 | 0.000000001 | 21 | ABCC4,ALB,APOE,AQP2,C1QA,CASP3,CCL2,CCL5,CXCL10,CYP27B1,DBP,EGR1,ETS1,F3,FAT1,IL1B,INF2,KIRREL,LRP1,mir-193,MYD88,NCF1,NFKBIA,NOS2,NPHS1,NR1H4,PLAUR,RELA,SCNN1A,SLC14A1,SLC51A,TLR4,TNF,VDR,WT1 |
| Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking | 6 | 0.000001 | 18 | ACE,CAV1,Ccl2,CCL2,CCL4,CCL5,CFB,CXCL3,F2RL1,folic acid,GBP4,HGF,ICAM1,IL17RD,IL1B,IRF4,MAPK14,MYD88,NOS3,NTN1,PROC,PROCR,RELA,S1PR2,SMAD4,SMAD7,SMURF1,THBD,TLR2,TLR4,TNF,TNFRSF12A,TNFRSF1B,TNFSF12,YBX1 |
| Cell Death and Survival, Organismal Injury and Abnormalities, Renal Necrosis/Cell Death | 6 | 0.000001 | 16 | AGT,CD68,CDKN1A,Clec2d (includes others),Cyp4a14,D-glucose,DKK3,EGF,GLIS2,Gsta4,HLA-DMA,ITGB5,JAG1,Kap,MAP2K3,MAPK13,MTOR,NLRP3,PPIB,RHOA,SMAD3,SPC25,TCIRG1,TFE3,TGFB1,TSC22D1,VEGFA,VIM,YBX1 |
| Organismal Injury and Abnormalities, Cellular Movement, Cardiovascular System Development and Function | 5 | 0.00001 | 16 | aldosterone,BDKRB1,BDKRB2,BGN,BIRC2,COL18A1,COL1A1,COL1A2,COL3A1,COL4A2,COL4A3,CR1L,CTGF,CXCR3,D-glucose,DCN,EDN1,FAS,FBN1,FN1,GLIS2,HGF,IKBKB,MAP2K1,MAPK1,MAPK3,MAPK14,MGP,MMP2,NUDT19,NUPR1,SMAD3,TGFB1,TSC22D3,WFDC2 |
| Cellular Development, Cellular Growth and Proliferation, Organ Development | 5 | 0.00001 | 13 | ANGPT2,BAG1,CAMK2A,CDH1,CTNNB1,CYBA,DBNL,EGFR,FOXI1,ID2,KPNA2,MIR17HG,MMP7,MMP14,MMP23B,NDE1,PKD1,PKD2,PRKCSH,PROS1,PVALB,RHOB,SLC26A4,SLC4A1,TCF3 |
| Cellular Movement, Immune Cell Trafficking, Hematological System Development and Function | 4 | 0.0001 | 15 | Abcb1b,ATP1A1,AXL,CD9,Cdc42,COL4A3,D-glucose,EDNRB,FCER1G,FCGR2B,FN1,GAS6,HBEGF,IFNG,IGF1,IL18BP,IL1B,ILK,ITGA3,ITGB1,LAMA5,LAMB1,LAMB2,MMP9,NID1,NOS2,PDGFB,PLAT,SLC9A3,SOCS3,STAT3,THY1,TNF,TP53,VEGFA |
| Endocrine System Disorders, Gastrointestinal Disease, Metabolic Disease | 4 | 0.0001 | 11 | ABCA1,AGT,ARPC1B,BAX,BMP2,CA2,CALB1,D-glucose,EIF4EBP1,EIF4G1,FABP1,FOS,MLXIPL,nicotinic acid,PDCD4,PRKCA,SPP1,TGFB1,TRIM24,TRPV5,TSC2,VCAM1 |
| Cell Morphology, Organismal Injury and Abnormalities, Metabolic Disease | 3 | 0.001 | 12 | AGT,AGTR1,ANGPT2,APAF1,BMP4,BMPR1A,CP,CTNNB1,Cyp2c44,GAS2,HMOX1,HSPB1,IL1B,LCN2,MAPKAPK3,MGST1,MYC,NOX4,PTGS2,REN,SLC12A1,SLC2A1,SMAD1,SOX9,TCF4,TGFB1,TNF,TXNIP,VAMP3 |