Effects of LPS combined with ROT on non-motor behavior. Rats were given LPS (5 mg/kg, i.p. x1), and 7 months later received 20 injections of rotenone (0.5 mg/kg, s.c., 5 time/week for 4 weeks), and the tests was performed 10 days after the last dose of rotenone. A, Open-field traveling distance; B, Open-field central/local activity ration; C. Open arm/closed arm in elevated combined with maze test; D. Correct alternative rate in the Y maze test. Values are the mean ± SEM (n = 6–9).
*Significantly different from the control group, p < 0.05.