Table 1.
Biomechanical properties measured in the femoral mid-diaphysis by 3-point bending test.
| FEMUR (by 3-point bending test) | ||||
|---|---|---|---|---|
| vehicle 5-month-old |
RAGE inhibitor 5-month-old |
vehicle 16-month-old |
RAGE inhibitor 16-month-old |
|
| Yield Force (N) | 12.67 ± 2.38 | 14.81± 2.26 | 9.08 ± 3.37# | 9.23 ± 4.16 |
| Ultimate Force (N) | 15.09 ± 0.93 | 15.70 ± 1.31 | 16.86 ± 1.52 | 15.69 ± 2.87 |
| Displacement to Yield (μm) | 372.58 ± 37.86 | 419.13 ± 51.66 | 256.65 ± 122.07# | 280.42 ± 137.34 |
| Postyield Displacement (μm) | 642.63 ± 344.32 | 439.93 ± 147.15 | 332.56 ± 150.72# | 394.35 ± 70.29 |
| Total Displacement (μm) | 991.91 ± 327.71 | 773.72 ± 172.42 | 584.99 ± 92.72# | 633.75 ± 119.06 |
| Stiffness (N/mm) | 34.27 ± 3.79 | 36.11 ± 2.88 | 44.02 ± 8.09# | 43.81 ± 7.84 |
| Work to Yield (mJ) | 2.64 ± 0.76 | 3.35 ± 0.80 | 1.47 ± 1.27# | 1.66 ± 1.25 |
| Postyield Work (mJ) | 6.85 ± 3.20 | 5.55 ± 1.48 | 4.25 ± 1.84# | 4.56 ± 0.73 |
| Total Work (mJ) | 9.23 ± 3.19 | 8.39 ± 2.47 | 6.16 ± 1.77# | 5.52 ± 1.26 |
| Yield Stress (MPa) | 75.51 ± 19.78 | 71.99 ± 21.16 | 48.16 ± 18.39# | 49.46 ± 22.18 |
| Ultimate Stress (MPa) | 91.83 ± 11.62 | 86.58 ± 9.87 | 89.98 ± 10.44 | 84.14 ± 12.12 |
| Strain to Yield (mε) | 365.29 ± 56.95 | 341.73± 111.10 | 307.97 ± 152.87 | 301.48 ± 147.93 |
| Total Strain (mε) | 933.81 ± 322.76 | 713.88 ± 165.82* | 630.26 ± 106.21# | 687.64 ± 113.83 |
| Modulus (GPa) | 2.16 ±0.38 | 2.12 ± 0.15 | 2.20 ± 0.34 | 2.18 ± 0.47 |
| Resilience (MPa) | 1.50 ± 0.54 | 1.69 ± 0.47 | 0.85 ± 0.75# | 0.95 ± 0.72 |
| Toughness (MPa) | 5.20 ± 2.14 | 4.03 ± 1.05 | 3.56 ± 1.10# | 3.53 ± 1.01 |
#
p<0.05 versus treatment-matched young mice;
*
p<0.05 versus age-matched vehicle-treated mice, by two-way ANOVA (n=7–9).