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. 2019 May 24;9:173. doi: 10.3389/fcimb.2019.00173

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Copyright © 2019 Gao, Yuan, Liu, Liu, Zhou, Yang, Duan, Guo, Liang, Hu, Tian and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MnmE contributes to SS2 pathogenicity in vivo and in vitro. (A) Survival curves for mice in experiment infection. Ten mice in each group were separately injected intraperitoneally with 3 × 10⁹ CFU/mice of SC19 and ΔmnmE. Ten mice were inoculated with saline and served as negative control. Significant difference in survival between different groups were analyzed by Log Rank test (p < 0.01). (B) Cell-associated bacteria recovered after incubation with HEp-2 cells. The mutant strain ΔmnmE showed significantly reduced levels of adherence to HEp-2 cells compared with the degree of adherence of SC19 and CΔmnmE (p < 0.05). (C) Bacteria invasion of HEp-2 cells. The mutant strain ΔmnmE showed significantly reduced levels of invasion of HEp-2 cells compared with that of SC19 and CΔmnmE (p < 0.01). Statistical significance was determined by two-tailed t-test (^*p < 0.05; ^**p < 0.01).