Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 30;19:519. doi: 10.1186/s12885-019-5741-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 3 — Proposed mechanism of nivolumab transport to the CSF. Neonatal Fc receptor mediated antibody transport from the blood vessels in the choroid plexus to the CSF. The choroid plexus consists of a monolayer of cuboidal epithelial cells in which macrophages reside [41]. The epithelial cells have microvilli and are interconnected via tight junctions forming the blood-CSF barrier. The proposed mechanism of FcRn mediated endocytosis of IgG4 monoclonal antibodies with FcRn binding like nivolumab is via macrophages residing in the choroid plexus [29, 41]. Monoclonal antibodies with FcRn binding like nivolumab are prevented from degradation by the FcRn [29]. The FcRn mediates antibody transport to the CSF. FcRn neonatal Fc receptor, CSF cerebrospinal fluid, IgG4 immunoglobulin G4