Fig. 2.

Correlations between soluble CD62L and predetermined parameters in SCD individuals. a Soluble CD62L correlated closely with percent circulating aged neutrophils, supporting the utilization of CD62L as the surrogate for circulating aged neutrophils in our subsequent experiments. b Serum LPS correlated positively with soluble CD62L, suggesting the role of LPS in modulating circulating aged neutrophils. c iFABP correlated negatively with serum LPS, and d with soluble CD62L in SCD, raising the possibilities that either DAMPs induced by intestinal injury modulate intestinal microbial density, or rapid cell turnover of enterocytes induced by intestinal injury produces new enterocytes well-endowed with functional tight junctions that reduce bacterial product translocation across the intestinal barrier