Figure 1.

Supervised hierarchical clustering of PHBI (Pulmonary Hypertension Breakthrough Initiative) classifier discovery genelist. The PHBI classifier is visualized by supervised hierarchical clustering of the PHBI dataset showing 99% correct identification of the pulmonary arterial hypertension (PAH) and failed donor (FD) samples into separate branches of the dendrogram. One PAH (idiopathic PAH subgroup) sample was misclassified as FD. Figures E1 and E2 show the batch and sex correction process, as well as independent validation of the PHBI classifier on independent lung PAH transcriptome datasets and literature-derived PAH-specific gene pathways.