Table 3.
Top Ranked Pathways and Upstream Regulators from Ingenuity Pathways Analysis
| P Value | z-Score | ||
|---|---|---|---|
| Ingenuity canonical pathways | |||
| Phagosome formation | 7.41E−07 | — | |
| G protein–coupled receptor signaling | 1.17E−06 | — | |
| IL-8 signaling | 4.57E−06 | −1.04 | |
| Role of pattern recognition receptors in recognition of bacteria and viruses | 6.76E−06 | −0.53 | |
| Complement system | 2.04E−05 | 1.34 | |
| Osteoarthritis pathway | 4.68E−05 | −0.23 | |
| cAMP-mediated signaling | 4.90E−05 | −0.63 | |
| tRNA splicing | 5.01E−05 | — | |
| Hepatic fibrosis/hepatic stellate cell activation | 6.03E−05 | — | |
| Upstream regulator | P value of overlap | Activation z-score | Predicted activation state |
| TNF | 1.24E−14 | −0.97 | — |
| CSF3 | 3.85E−12 | −2.42 | Inhibited |
| β-estradiol | 1.29E−11 | −0.85 | — |
| LPS | 4.00E−11 | −1.41 | — |
| Ig | 1.47E−10 | 3.64 | Activated |
| IL-13 | 2.19E−10 | 1.37 | — |
| TGFB1 | 7.02E−10 | 0.93 | — |
| TCL1A | 1.35E−09 | −2.00 | Inhibited |
| Tretinoin | 2.71E−09 | −1.72 | — |
| Dexamethasone | 1.21E−08 | −1.39 | — |
| TGM2 | 1.98E−08 | −4.03 | Inhibited |
| ESR1 | 2.70E−08 | 1.51 | — |
| GNA12 | 3.06E−08 | 1.14 | — |
| IL-10RA | 3.82E−08 | 2.47 | Activated |
| OSM | 7.60E−08 | 1.62 | — |
| IL-10 | 8.48E−08 | −2.39 | Inhibited |
Definition of abbreviations: CSF = colony-stimulating factor; ESR = estrogen receptor; GNA = G protein subunit α; IL-10RA = IL-10 receptor A; OSM = oncostatin M; TCL = T cell leukemia/lymphoma; TGF = transforming growth factor; TGM = transglutaminase.