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. 2019 May 24;10:1128. doi: 10.3389/fimmu.2019.01128

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Copyright © 2019 Walter, Vielmuth, Wanuske, Seifert, Pollmann, Eming and Waschke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of signaling pathways activated by pemphigus autoantibodies directed against Dsg1 and Dsg3. Src and EGFR activation is associated with antibodies targeting Dsg3 whereas autoantibody fractions against Dsg1 induce ERK activation and Ca²⁺ influx.