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. 2019 May 24;13:237. doi: 10.3389/fncel.2019.00237

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Copyright © 2019 Serdar, Kempe, Rizazad, Herz, Bendix, Felderhoff-Müser and Sabir.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pro-inflammatory cytokine expression 24 h after inflammation-sensitized hypoxic-ischemic brain injury. (A) In the hippocampus pro-inflammatory genes of iNOS, IL-1beta and IL-6 were significantly upregulated in animals pre-sensitized with LPS undergoing a mild HI injury. (B) In the cortex, IL-6 was significantly upregulated, whilst IL-12 was downregulated after inflammation-sensitized hypoxic-ischemic brain injury. Group sizes: Sham n = 7, LPS n = 7, Veh/HI n = 12, LPS/HI n = 12; ^∗p < 0.05, ^∗∗p < 0.01.