Table 1.
% Growth inhibition of compounds 5c, 5d and 5f.
| Panel/Cell Line | % Growth inhibition |
Panel/Cell Line | % Growth inhibition |
||||
|---|---|---|---|---|---|---|---|
| Compound |
Compound |
||||||
| 5c | 5d | 5f | 5c | 5d | 5f | ||
| Leukemia | Melanoma | ||||||
| CCRF-CEM | 40.64 | −0.22 | 20.48 | LOX IMVI | 25.61 | 5.8 | 10.87 |
| HL-60 (TB) | 29.58 | 1.34 | 38.21 | MALME-3M | 4.81 | −4.03 | 5.73 |
| K-562 | 32.42 | 7.18 | 50.66 | M14 | 40.08 | 7.13 | 24.61 |
| MOLT-4 | 38.9 | 11.42 | 34.78 | MDA-MB-435 | 24.92 | 5.38 | 22.95 |
| RPMI-8226 | 48.96 | 19.75 | 44.48 | SK-MEL-2 | 10.03 | −6.35 | 0.73 |
| SR | 11.28 | 1.58 | 39.13 | SK-MEL-28 | 8.57 | −10.44 | 5.82 |
| Non-Small Cell Lung Cancer | SK-MEL-5 | 29.89 | 1.76 | 31.01 | |||
| A549/ATCC | 39.14 | 11.24 | 45.14 | UACC-257 | 2.92 | 1.42 | 30.59 |
| EKVX | 45.94 | 17.74 | 13.24 | UACC-62 | 33.69 | 15.86 | 28.42 |
| HOP-92 | 29.11 | 15.01 | 2.89 | Ovarian Cancer | |||
| HOP-92 | 21.85 | 17.02 | 16.19 | IGROV1 | 19 | −5.64 | 1.44 |
| NCI-H226 | 37.29 | 1.65 | 15.64 | OVCAR-3 | — | 1.23 | 18.03 |
| NCI-H23 | 21.39 | 5.79 | 6.86 | OVCAR-4 | 28.3 | 6.36 | 21.38 |
| NCI-H322M | 15.54 | 8.05 | −0.13 | OVCAR-5 | 15.26 | −0.62 | 7.95 |
| NCI-H460 | 22.73 | −6.31 | 38.84 | OVCAR-8 | 20.76 | 6.85 | 37.13 |
| NCI-H522 | 43.07 | 40.92 | 4.23 | NCI/ADR-RES | 19.47 | −3.89 | 5.59 |
| Colon Cancer | SK-OV-3 | 18.61 | 11.82 | 1.64 | |||
| COLO 205 | 6.67 | −14.94 | 28.99 | Renal Cancer | |||
| HCC-2998 | 6.4 | −9.24 | 14.04 | 786-0 | 25.18 | 2.86 | 12.87 |
| HCT-116 | 48.8 | 5.9 | 48.64 | A498 | 15.07 | 15.4 | 16.67 |
| HCT-15 | 38.9 | 18.27 | 31.67 | ACHN | 72.83 | 4.67 | 6.49 |
| HT29 | 31.43 | 17.77 | 63.81 | CAKI-1 | ——— | ——— | ——— |
| KM12 | ——— | −1.93 | 32.87 | RXF 393 | 28.4 | −2.11 | 25.4 |
| SW-620 | 2.92 | −11.86 | 21.43 | SN12C | 11.57 | 3.69 | 31.97 |
| CNS Cancer | TK-10 | 3.2 | −12.49 | 10.36 | |||
| SF-268 | ———— | 5.69 | 8.88 | UO-31 | 54.99 | 38.03 | 61.91 |
| SF-295 | 33.22 | 11.51 | 34.62 | Breast Cancer | |||
| SF-539 | 11.92 | 2.56 | 0.75 | MCF7 | 57.57 | 32.37 | 70.28 |
| SNB-19 | 5.7 | 0.31 | 22.56 | MDA-MB-231 | 25.7 | 10.27 | 11.47 |
| SNB-75 | 34.78 | 29.2 | 9.78 | HS 578T | 20.95 | 4.66 | 21.21 |
| U251 | 27.74 | 0.31 | 37.8 | BT-549 | 27.92 | 17.36 | 22.29 |
| Prostate Cancer | T-47D | 55.67 | 33.16 | 51.28 | |||
| PC-3 | 52.88 | 19.04 | 77.28 | MDA-MB-468 | 30.96 | −3 | 12.66 |
| DU-31 | ———— | −3.61 | 13.84 | ||||