Table 1.

Growth percent (G%) of the NCI-60 panel tumor cell lines at 10⁻⁵ M concentration of compounds 3a, 3b, 3e, 5a, 5b and 6.

Tumor cell lines	Growth percent (G%)
	3a	3b	3e	5a	5b	6
Leukemia
CCRF−CEM	20.72	29.04	19.07	92.93	2.47	17.76
HL−60(TB)	2.26	94.52	ND	104.29	−18.8	7.05
K−562	55.20	12.90	68.79	89.61	28.57	26.84
MOLT−4	5.55	18.44	2.39	87.37	−24.49	16.13
RPMI−8226	62.72	4.83	51.06	100.23	33.49	19.65
SR	43.80	33.72	ND	92.01	80.76	11.44
Non−small cell lung cancer
A549/ATCC	97.18	−0.05	81.67	85.17	82.36	37.73
EKVX	27.35	15.17	70.67	ND	ND	ND
HOP−62	118.63	−38.70	81.77	80.81	80.29	36.07
HOP−92	71.42	−37.24	100.92	99.17	50.81	80.01
NCI−H226	78.47	−28.80	73.22	88.55	99.44	86.30
NCI−H23	65.95	21.21	78.33	86.15	66.79	38.22
NCI−H322M	89.28	13.98	96.16	91.04	97.72	63.53
NCI−H460	68.27	−69.73	78.50	108.09	83.68	33.57
NCI−H522	54.81	−16.76	50.55	78.37	65.5	19.42
Colon cancer
HCC−2998	102.57	65.07	101.82	103.64	100.59	42.85
HCT−116	55.46	−12.24	71.69	99.77	34.6	41.72
HCT−15	44.70	−31.10	85.01	94.13	79.63	66.56
HT29	102.52	66.37	73.69	96.96	63.02	84.18
KM 12	66.22	0.12	91.54	95.63	86.61	18.86
SW−620	89.23	−53.04	86.24	103.1	73.47	18.61
CNS cancer
SF−268	91.30	−31.69	95.35	101.09	84.32	34.32
SF−295	92.71	−1.34	ND	101.32	95.07	18.38
SF−539	90.30	−27.99	97.17	93.83	89.92	−5.45
SNB−19	103.72	7.11	93.29	110.38	90.17	27.87
SNB−75	112.98	−9.01	64.39	101.36	119.73	31.77
U251	79.04	−77.55	90.22	104.35	57.67	21.15
Melanoma
LOX IMVI	56.12	11.13	76.59	95.89	32.39	42.99
MALME−3M	124.29	−51.66	113.45	113.29	112.5	42.00
M14	73.38	10.44	85.59	98.25	89.81	44.74
MDA−MB−435	83.72	10.25	103.73	105.3	95.88	87.80
SK−MEL−2	76.92	31.83	92.64	86.85	79.89	23.06
SK−MEL−28	112.03	−11.84	111.89	107.21	106.96	39.37
SK−MEL−5	79.73	12.31	76.95	97.56	67.42	17.66
UACC−62	88.73	75.08	77.03	93.45	63.95	13.17
Ovarian cancer
IGROV1	55.11	−3.63	68.65	65.92	68.31	71.85
OVCAR−3	−14.81	−68.37	21.58	98.93	−16.31	2.15
OVCAR−4	−5.49	−42.04	4.38	97.38	−99.52	18.80
OVCAR−5	102.37	52.70	119.92	102.02	117.77	88.70
OVCAR−8	35.61	−27.45	85.32	100.1	10.25	48.24
SK−OV−3	104.46	1.64	93.55	95.03	102.05	67.28
Renal cancer
A498	103.58	80.44	93.29	ND	ND	ND
ACHN	65.70	−14.18	75.49	85.7	79.61	28.55
RXF 393	97.24	−46.34	100.91	87.68	72.63	69.20
SN12C	70.40	−26.26	81.84	125.68	106.07	−14.11
UO−31	60.44	−54.91	54.76	137.02	112.5	64.18
Prostate cancer
PC−3	65.49	−33.26	64.38	79.23	81.82	49.16
DU−145	82.02	−45.39	90.97	81.38	42.4	34.21
Breast cancer
MCF7	48.82	0.70	68.38	76.73	92.37	51.60
BT−549	73.94	37.99	77.38	104.21	93.67	12.26
T−47D	22.52	−58.11	9.70	83.56	85.06	4.47
MDA−MB−468	−8.43	−32.41	−9.91	64.82	−9.96	−27.29
Average G%	68.19	−4.69	74.32	95.45	65.81	35.49

ND, Not determined.