Table 2.

The main cytotoxic parameters (GI₅₀, TGI and LC₅₀) of compound 3b in μM.

Tumor cell lines	GI ₅₀	TGI	LC ₅₀
Leukemia
CCRF-CEM	0.41	4.86	> 100
HL-60 (TB)	1.70	5.25	34.76
K-562	0.37	2.00	50.12
MOLT-4	0.44	3.16	> 100
RPMI-8226	0.39	2.63	> 100
SR	0.50	3.98	> 100
Non-small cell lung cancer
A549/ATCC	1.02	2.88	8.32
EKVX	0.25	2.45	26.30
HOP-62	0.20	0.65	3.24
HOP-92	0.15	0.39	1.00
NCI-H226	0.14	0.35	0.87
NCI-H23	0.35	1.82	7.08
NCI-H322M	0.32	1.45	7.24
NCI-H460	0.22	0.49	1.48
NCI-H522	0.32	1.38	8.13
Colon cancer
COLO 205	10.47	27.54	72.44
HCC-2998	063	2.57	9.12
HCT-116	0.31	1.10	4.57
HCT-15	0.21	0.51	2.00
HT29	3.72	12.88	39.81
KM 12	0.45	3.02	27.54
SW-620	0.33	1.00	7.59
CNS cancer
SF-268	0.46	3.98	48.98
SF-295	0.63	2.29	6.61
SF-539	0.23	0.56	2.09
SNB-19	0.31	1.10	6.17
SNB-75	0.16	0.42	1.29
U251	0.27	0.76	2.82
Melanoma
LOX IMVI	0.32	1.32	3.98
MALME-3M	0.23	044	0.85
M14	0.40	1.51	4.57
MDA-MB-435	0.30	1.20	4.07
SK-MEL-2	1.74	5.13	19.95
SK-MEL-28	0.34	1.23	4.68
SK-MEL-5	1.30	1.20	3.72
UACC-257	1.32	3.39	8.51
UACC-62	0.28	1.15	3.98
Ovarian cancer
IGROV1	0.22	0.74	3.47
OVCAR-3	0.24	0.56	1.82
OVCAR-4	0.17	0.45	1.51
OVCAR-5	3.47	14.79	40.74
OVCAR-8	0.39	2.29	30.20
NCI/ADR-RES	0.35	1.78	34.67
SK-OV-3	0.35	1.78	5.62
Renal cancer
786–0	0.22	0.54	2.45
A498	0.21	0.95	3.55
ACHN	0.20	0.58	2.63
RXF 393	0.21	0.58	2.51
SN12C	0.20	0.47	1.35
TK-10	0.38	1.10	6.03
UO-31	0.19	0.60	2.51
Prostate cancer
PC-3	0.18	0.46	1.58
DU-145	0.28	0.78	12.30
Breast cancer
MCF7	0.23	1.05	18.62
MDA-MB-231/ATCC	0.17	0.51	2.82
HS 578 T	0.26	1.38	> 100
BT-549	0.30	1.32	6.76
T-47D	0.26	0.98	5.13
MDA-MB-468	0.25	0.87	4.57