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Selectivity of the tested compounds.
| 3a IC50a (μM) |
3b IC50a (μM) |
5a IC50a (μM) |
6 IC50a (μM) |
|
|---|---|---|---|---|
| ERK1 (100 μiM ATP) | 9.12 ± 1.1 | 0.5 ± 0.09 | 95 ± 10.9 | 0.19 ± 0.01 |
| ERK2 (100 μM ATP) | 10.2 ± 1.2 | 0.6 ± 0.1 | 108 ± 12.2 | 0.16 ± 0.02 |
| ERK2 (10 μM ATP) | 0.2 ± 0.01 | 0.086 ± 0.005 | ||
| JNK2 | > 200 | 24 ± 1.24 | > 200 | 4.2 ± 0.9 |
| p38MAPKα | > 200 | 27.9 ± 1.5 | > 200 | 3.1 ± 0.5 |
| A375 Cell Viability | 3.7 ± 0.6 | 0.13 ± 0.03 |
IC50 Determined as described in Methods section, Data were fitted to Eq. (1).
