Table 5.

Pharmacokinetic prediction of the synthesized compounds by Molinspiration v2016.10.

Compound	miLog Pa	TPSAb	nONc	nOHNHd	nviolation	Nrotbe	Mol Volf	MWtg	%ABSh
3a	3.08	80.14	5	1	0	0	256.10	315.28	81.35%
3b	3.73	80.14	5	1	0	0	269.63	349.73	81.35%
3c	3.86	80.14	5	1	0	0	273.98	394.18	81.35%
3d	3.50	80.14	5	1	0	0	272.66	329.31	81.35%
3e	3.59	69.29	5	0	0	0	273.04	329.31	85.09%
3f	3.97	69.29	5	0	0	1	289.84	343.34	85.09%
5a	4.39	99.50	7	0	0	1	334.38	411.37	74.67%
5b	4.02	99.50	7	0	0	0	317.58	397.34	74.67%
6	4.93	106.59	7	1	0	2	395.84	495.87	72.23%

^aLogarithm of partition coefficient between n-octanol and water (miLogP).

^bTopological polar surface area (TPSA).

^cNumber of hydrogen bond acceptors (n-ON).

^dNumber of hydrogen bond donors (n-OHNH).

^eNumber of rotatable bonds (n-rotb).

^fMolecular Volume.

^gMolecular weight (MWt).

^hPercentage of absorption (%ABS).