Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 24;10:1149. doi: 10.3389/fimmu.2019.01149

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Zhou, Yazdanifar, Roy, Whilding, Gavrill, Maher and Mukherjee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The MUC28z CAR T cells lyse TNBC tumor cells in vitro in an antigen-dependent manner. (A) Percentage of cells expressing tMUC1, determined by TAB004-APC/Cy5.5 staining and flow cytometry. A panel of nine TNBC cell lines and one “normal” mammary epithelial cell line hTERT-HME1 is shown. (B) Percentage of TNBC tumor cell lysis by MUC28z CAR T cells. Cells were co-cultured at E:T ratio of 5:1 for 3 days. The lysis of tumor cells was determined by MTT assay. Data are presented as the mean ± SEM. The relationship between tMUC1 positivity in TNBCs and tumor lysis by MUC28z CAR T cells was analyzed by a non-parametric Spearman correlation, with r = 0.8909 which was highly significant (P = 0.0011) and indicated a positive association between tMUC1 level and tumor lysis.