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. 2019 May 24;10:1149. doi: 10.3389/fimmu.2019.01149

Figure 5.

Figure 5

MUC28z CAR T cells reduce HCC70 tumor burden in vivo. (A) HCC70 tumor growth reduction by a single injection of MUC28z CAR T cells in vivo. HCC70 cells were orthotopically injected into the mammary fat pad of female NSG mice. When tumors were palpable, mice were randomized and received a single i.v. injection of PBS as vehicle control, or MUC28z CAR T cells on day 4 post-tumor cell challenge. Tumor growth was monitored by caliper measurement. Data are presented as the mean ± SD. The statistical analysis was performed by two-way ANOVA. ***p < 0.001. (B) The wet weight of resected tumor mass on day 57 at endpoint. Top is the tumor pictures at the endpoint. The weights of individual tumors are presented. ***p < 0.001 (student t-test). (C) Increase of activation/exhaustion markers on CD8+ MUC28z CAR T cells. MUC28z CAR T cells were stained right before i.v. injection and right after tumor infiltrating lymphocytes analysis from tumor mass. Cells were gated on CD8+ T cells.