Figure 1.

In vivo evaluation of the transplant's structural preservation. (A) OCT of the transplanted retina over time. One week (1W) after transplantation (D0), the host retina has reattached and maintains its laminar structure. After 1 month (1M), the OS of the transplant have grown back (yellow arrows) while its inner retina has thinned and this structure is still maintained at 3 months. (B) Time course of the transplant thickness, up to 4 months, averaged over eight animals (dots colored per animal). The data were fitted with an exponential function (red line), y = y_∞ + (y₀ − y_∞) · e^−t/τ with y_∞ = 88 ± 8 μm, y₀ = 217 ± 18 μm and τ = 3 ± 1 days (± indicate the 95% confidence interval). Note that animals were terminated at different time points, but all of them reached the steady state (t > 4τ). (C) Initial and steady-state thickness of the inner and outer layers of the transplant. The inner layers (GCL, IPL, INL) of the transplant decreased from 107 to 32 μm, while the outer layers (OPL, ONL, OS) decreased less, from 110 to 56 μm.