Summary of findings 3. Midline versus lateral insertion for preventing catheter‐related infections in chronic peritoneal dialysis patients.
| Midline versus lateral insertion for preventing catheter‐related infections in chronic peritoneal dialysis patients | |||||
| Patient or population: chronic peritoneal dialysis patients Intervention: midline insertion Comparison: lateral insertion | |||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | No. of participants (studies) | Certainty of the evidence (GRADE) | |
| Risk with lateral | Risk with midline | ||||
| Peritonitis | 255 per 1,000 | 166 per 1,000 (82 to 339) | RR 0.65 (0.32 to 1.33) | 120 (2) | ⊕⊕⊕⊝ MODERATE 1 |
| Exit‐site/tunnel infection | 78 per 1,000 | 44 per 1,000 (9 to 202) | RR 0.56 (0.12 to 2.58) | 120 (2) | ⊕⊕⊝⊝ LOW 2 |
| Catheter removal or replacement | 514 per 1,000 | 293 per 1,000 (170 to 504) | RR 0.57 (0.33 to 0.98) | 83 (1) | ⊕⊝⊝⊝ VERY LOW 3 |
| Death (all causes) | 0 per 1,000 | 0 per 1,000 (0 to 0) | RR 8.50 (0.50 to 143.32) | 37 (1) | ⊕⊝⊝⊝ VERY LOW 3 |
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio | |||||
| GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | |||||
1 Downgraded one level: suboptimal quality of studies
2 Downgraded two levels: suboptimal quality and imprecision
3 Downgraded three levels: single study, suboptimal quality study, and imprecision