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. 2019 May 31;12(3):313–321. doi: 10.1093/ckj/sfz070

FIGURE 2.

FIGURE 2

Efficacy of nephroprotective therapies. (A) Relative risk or HR for primary endpoint (IDNT and RENAAL: doubling of the serum creatinine concentration, ESRD or death; CANVAS: doubling of the serum creatinine concentration, ESRD or cardiovascular or renal death). SONAR was omitted because the primary endpoint did not include death. (B) Relative risk or HR for key renal endpoints explored in all the trials. The original IDNT manuscript did not provide the combined doubling of the serum creatinine concentration and ESRD endpoint. (C) Residual risk for key renal endpoints. In IDNT, the residual risk per 100 person-years was estimated from mean follow-up and percentage of patients with events. Data from references [2–4]. The comparator for RENAAL and IDNT was placebo/absence of RAS blockade, whereas the comparator for CREDENCE and SONAR was placebo + RAS blockade.