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. 2019 May 14;13:162. doi: 10.3389/fnhum.2019.00162

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Copyright © 2019 Al-Zubaidi, Heldmann, Mertins, Brabant, Nolde, Jauch-Chara and Münte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glucose-associated low-frequency BOLD fluctuations. (A) The Δ (hunger-satiety) of fALFF in Fusiform connected with Δ glucose plasma after glucose administration. The statistical image was assessed for cluster-wise significance using a cluster defining threshold P < 0.001, 0.05 false discovery rate (FDR) corrected at the cluster level. (B) Amplitude of BOLD signal in the fusiform gyrus and plasma glucose levels in the hunger and satiety states. (C) The LOOCV showed that a positive correlation (r = 0.75) between the average Δ fALFF value of fusiform cluster and Δ plasma glucose, adjusted for Δ plasma insulin level. LOOCV, leave-one-out cross-validation.