Chart 3.
Systemic treatments for HS according to the level of evidence and grade of recommendation based on the literature
| Intervention | Level of evidence/Grade of recommendation | |
|---|---|---|
| Oral antibiotics | ||
| Trimethoprim/sulfamethoxazole | IV/D | |
| Tetracyclines (tetracycline) | II/B | |
| Clindamycin + rifampicin | III/C | |
| Clindamycin + ofloxacin | III/C | |
| Oral retinoids | ||
| Acitretin | II/C | |
| Isotretinoin | IV/D | |
| Antiandrogens | ||
| Metformin | II/B | |
| Finasteride | III/C | |
| Ethynilestradiol | III/C | |
| Anti-inflammatories and immunosuppressants | ||
| Systemic steroid | IV/D | |
| Dapsone | III/C | |
| Zinc | III/C | |
| Biologics | ||
| Adalimumab | I/A | |
| Infliximab | II/B | |
| Etanercept | III/C | |
| Anakinra | III/C | |
| Canakinumab | IV/D | |
| Ustekinumab | III/D | |
| Secukinumab | IV/D | |
| Apremilast | IV/D |