Skip to main content
. Author manuscript; available in PMC: 2019 May 31.
Published in final edited form as: Dev Biol. 2017 Aug 1;430(1):32–40. doi: 10.1016/j.ydbio.2017.07.012

Fig. 2.

Fig. 2.

IFT172 is required for patterning and morphogenesis of the optic cup. (A) Sections through E10.5 wild-type and Ift172 mutant eyes stained with markers for cell fates. Note the dorsal expansion of PAX2, dorsal restriction of PAX6, expansion of MITF and OTX2 into the inner optic cup, reduction in CHX10+ cells and loss of SOX2 expression in the Ift172 mutant. Abbreviations: OS, optic stalk; RPE, retinal pigment epithelium; NR, neural retina; P, proximal; Di, distal; Do, dorsal; V, ventral. (B) Sections through E11.5 wild-type, Ift172 mutant and Gli3 mutant eyes stained with markers for cell fates. Note the dorsal expansion of PAX2, dorsal restriction of PAX6, expansion of MITF and OTX2 into the inner optic cup, reduction of CHX10+ cells, distal expansion of SOX1, and loss of SOX2 expression in both Ift172 and Gli3 mutants.