Table 2.
Frequency of adverse effects by 6 dose levels of trientine (n = 17).
| Level | I (n = 3) | II (n = 3) | III (n = 3) | IV (n = 3) | V (n = 3) | VI (n = 2) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trientine (mg/day) | 300 | 600 | 900 | 1200 | 1500 | 1800 | |||||||||||||
| LipoDox 40 mg/m2 and carboplatin AUC 4 q4w | |||||||||||||||||||
| CTCAE v4.0 grade | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 |
| Leukopenia | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 0 | 2 | 2 | 0 | 0 | 0 | 0 |
| Neutropenia | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Anemia | 3 | 2 | 0 | 1 | 1 | 0 | 2 | 3 | 1 | 0 | 2 | 2 | 1 | 3 | 2 | 0 | 1 | 1 | 0 |
| Thrombocytopenia | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nausea | 2 | 2 | 0 | 2 | 0 | 0 | 2 | 1 | 0 | 0 | 3 | 1 | 0 | 3 | 0 | 0 | 1 | 0 | 0 |
| Vomiting | 1 | 2 | 0 | 2 | 0 | 0 | 2 | 0 | 1 | 0 | 3 | 1 | 0 | 3 | 0 | 0 | 1 | 0 | 0 |
| Constipation | 1 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| Diarrhea | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mucositis | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 3 | 1 | 0 | 1 | 0 | 0 |
| Numbness (Paresthesia) | 1 | 0 | 0 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 |
| Dizziness | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 |
| Fatigue | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
| Anorexia | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 0 | 0 | 3 | 2 | 0 | 3 | 1 | 0 | 1 | 1 | 0 |
| Hand-foot syndrome | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 |
| Skin rash | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 1 | 0 | 0 | 0 | 0 |
| Alopecia | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 0 | 2 | 0 | 0 |
| Fever | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Hyponatremia | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Hyperkalemia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| AST increased | 3 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
| ALT increased | 3 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| ALK-P increased | 2 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
AST/GOT, Aspartate aminotransferase; ALT/GPT, Alanine aminotransferase; ALK-P, Alkaline phosphatase.