Table 5.
Changes in serum levels of ceruloplasmin, copper, and iron, urine levels of copper and zinc related to treatment response.
| PD (n = 9) | SD ≥ 4 M/PR/CR (n = 7) | p-value | |
|---|---|---|---|
| Serum Ceruloplasmin (mg/dL) | |||
| Baseline | 45.25 (17.96) | 42.44 (15.11) | 1.000 |
| After one cycle | 46.76 (17.97) | 36.25 (6.72) | 0.315 |
| After three cycle | 49.10 (12.31) | 33.47 (5.90) | 0.100 |
| Nadir | 41.26 (15.78) | 38.23 (16.90) | 0.385 |
| Serum Copper (μg/dL) | |||
| Baseline | 143.50 (68.99) | 131.57 (41.84) | 0.862 |
| After one cycle | 152.60 (41.74) | 109.33 (28.25) | 0.120 |
| After three cycle | 157.20 (40.07) | 93.50 (26.04) | 0.022 |
| Nadir | 128.50 (40.25) | 106.43 (42.63) | 0.247 |
| Serum Iron (μg/dL) | |||
| Baseline | 35.50 (16.69) | 62.83 (22.09) | 0.030 |
| After one cycle | 49.80 (18.13) | 64.00 (16.16) | 0.234 |
| After three cycle | 55.75 (12.74) | 60.00 (16.54) | 1.000 |
| Nadir | 35.50 (16.69) | 52.50 (15.54) | 0.090 |
| Urine Copper | |||
| Baseline (μg/dL) | 2.55 (2.74) | 2.94 (2.82) | 0.561 |
| Day 14 (24 h) (μg) | 83.74 (12.44) | 94.22 (59.78) | 1.000 |
| Day 64 (24 h) (μg) | 128.80 (–) | 158.53 (129.56) | 1.000 |
| Urine Zinc | |||
| Baseline (μg/dL) | 49.70 (41.74) | 55.07 (76.73) | 0.654 |
| Day 14 (24 h) (μg) | 949.32 (896.66) | 993.45 (379.33) | 0.518 |
| Day 64 (24 h) (μg) | 910.00 (–) | 1163.79 (929.82) | 1.000 |
Data was presented as mean (SD) and data was analyzed by Mann-Whitney U-test. CR, complete response; PR, partial response; PD, progressive disease; SD, stable disease.