Table 2. Substrate scope-1.
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| Entry | R1 | R2 | R3 | T/°C | (E)-2 yield a /% |
| 1 | Me | 4-pyridyl | Ph (1a) | 60 | 82 (2a) |
| 2 | Me | 3-Pyridyl | Ph (1b) | 60 | 80 (2b) |
| 3 | Me | 2-Pyridyl | Ph (1c) | 60 | 62 (2c) |
| 4 | Me | 3-Quinolinyl | Ph (1d) | 60 | 71 (2d) |
| 5 | Me | 4-Pyridyl | 4-MeC6H4 (1e) | 60 | 89 (2e) |
| 6 b | Me | 4-Pyridyl | n-Bu (1f) | 70 | 86 (2f) |
| 7 b | Me | 4-Pyridyl | n-C8H17 (1g) | 70 | 81 (2g) |
| 8 | Et | 4-Pyridyl | Ph (1h) | 60 | 88 (2h) |
| 9 c | Ph | 4-Pyridyl | n-Bu (1i) | 75 | 81 (2i) |
| 10 d | Me | 4-O2NC6H4 | n-C6H13 (1j) | 70 | 58 (2j) |
aIsolated yield.
bWith 6 mol% Pd(TFA)2 and 9 mol% DPEphos.
cWith 6 mol% Pd(TFA)2, 9 mol% DPEphos, and 6.0 mmol of MeOH for 24 h.
dWith 4 mol% Pd(TFA)2, 8 mol% DPEphos, and 4.0 mmol of MeOH.