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Proportion of patients who achieved target serum uric acid levels (<6 mg/dL) with lesinurad in combination with allopurinol. Pooled data from CLEAR 1 and CLEAR 2. Reproduced from Zurampic et al.17
| Timepoint | Placebo + allopurinol N=407 | Lesinurad 200 mg + allopurinol N=405 | Lesinurad 200 mg versus placebo |
|---|---|---|---|
| Months 4, 5, 6 | 48 (12%) | 155 (38%) | 0.26 (0.21, 0.32) |
| Month 6 | 104 (26%) | 222 (55%) | 0.29 (0.23, 0.36) |
| Month 12 | 105 (26%) | 203 (50%) | 0.24 (0.18, 0.31) |
