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Proportion of patients who were reported to suffer kidney stone TEAEs in the pivotal studies of lesinurad.
| XOI alone * | Lesinurad 200 + XOI | Lesinurad 400 + XOI | |
|---|---|---|---|
| CLEAR 1 (allopurinol) | 2.0% | 1.0% | 2.5% |
| CLEAR 2 (allopurinol) | 0.5% | 0% | 3.0% |
| CRYSTAL (febuxostat) | 3.7% | 0.9% | 1.8% |
TEAEs, treatment-emergent adverse effects; XOI, xanthine oxidase inhibitor.
