Fig. 6. Predicted intermodular interactions between the N-terminal domain of FGF-23 and the antagonist compounds.

(A to H) FTMap-based predictions of Zinc13407541 interaction with Asn112 (A and B), Gin131 (C), Tyr132 (D), Glu111 (E), Ser155 (F), Leu138 (G), and Arg140 (H) of the N terminus of FGF-23. (I) FTMap-based prediction of hydrogen bond formations between Zinc13407541 and Zinc 01626100 with the side chain of Ser155. (J and K) FTMap-based prediction of Zinc01626100 interaction with the backbone oxygen of Tyr154 (J) and the side chain of Thr44 (K).