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. 2019 May 31;14(5):e0216793. doi: 10.1371/journal.pone.0216793

Table 3. Results of differential expression analysis of T1 clusters with sufficient number of samples (Clusters 2 to 6) with cluster 1 (n = 103) as a reference and results of differential expression analysis of T3 clusters with sufficient number of members (Cluster 2 through 4), using Cluster 1 (n = 66) as a reference group.

Gene Symbol Entrez T1 T3
Cluster 2 (n = 91) Cluster 3 (n = 12) Cluster 4 (n = 11) Cluster 5 (n = 42) Cluster 6 (n = 11) Cluster 2 (n = 36) Cluster 3 (n = 43) Cluster 4 (n = 29)
logFC FDR logFC FDR logFC FDR logFC FDR logFC FDR logFC FDR logFC FDR logFC FDR
A2 vs A1                                  
KIDINS220 57498                 -0.82 2.10E-05     -0.27 1.53E-02 -0.74 2.94E-07
MAP7 9053 0.52 1.36E-05 -0.78 5.00E-03 -0.79 3.56E-03 -1.18 8.05E-14 -2.16 1.37E-12 -0.99 3.68E-05 -1.71 3.26E-15 -2.65 4.03E-16
IL6 3569 -0.88 5.45E-03 1.65 3.36E-03 -2.05 7.15E-03 3.17 3.06E-20 3.19 4.27E-11 1.80 9.49E-05 3.57 9.61E-19 4.07 1.89E-18
ATP6V1G1 9550         0.97 3.41E-18 -0.20 1.78E-02 -0.55 5.02E-05     -0.24 7.85E-03    
BACH1 571 -0.39 2.99E-05     -0.68 7.90E-04             0.47 3.71E-05    
RCAN1 1827 0.53 2.13E-03     -1.44 3.20E-04 -0.67 4.80E-03 -1.17 4.15E-03 -0.71 2.06E-02 -1.08 1.79E-05 -1.66 3.49E-06
PLPP3 8613         -0.83 6.16E-04 -0.65 7.16E-06 -1.31 3.23E-07     -0.73 1.25E-06 -2.21 5.64E-23
TRMT10B 158234             -0.40 2.32E-03 -0.80 3.27E-04     -0.39 1.95E-02    
FRMD3 257019     -0.74 8.62E-03 -1.66 6.82E-09 -0.99 5.04E-10 -2.85 4.06E-19 -0.64 2.47E-03 -1.12 2.63E-10 -1.69 3.77E-11
MYOZ1 58529     0.97 1.48E-03         -2.29 2.33E-08     0.56 2.37E-02    
PTAR1 375743     -0.49 3.95E-02     -0.68 3.08E-07 -1.50 6.71E-10 -0.46 1.32E-03 -0.66 7.06E-08 -0.91 7.45E-08
RUSC2 9853         -0.97 3.65E-07 -0.25 3.76E-02 -1.19 2.20E-09 -0.33 4.12E-02 -0.37 4.66E-03    
SHISA4 149345 -0.35 1.84E-03 0.97 2.91E-06 0.44 4.96E-02 0.59 2.22E-05 0.92 1.60E-05 0.53 1.12E-02 0.77 4.53E-06 1.33 8.18E-11
A2 vs A3                                  
AOC1 26 0.66 1.90E-02     -4.37 2.76E-08 -0.95 1.40E-02 1.39 6.78E-03            
ACSM2B 348158 1.10 5.32E-08 -5.35 1.91E-18 -3.27 3.15E-09 -1.23 1.56E-05 -1.03 3.76E-02     -1.98 1.73E-10 -3.85 7.20E-15
PAX2 5076     2.14   -1.62 1.65E-07 -0.77 1.13E-05   3.72E-45     -1.02 1.26E-04 -0.80 2.88E-02
PTPRH 5794 -1.06 6.86E-05 -5.98 1.15E-06     3.32 1.70E-30 5.17 4.22E-05 1.49 3.69E-04 2.26 2.10E-10 4.57 6.27E-29
SLC22A2 6582     -2.55 1.04E-23 -3.40 1.04E-10 -0.98 2.88E-04 -2.02 1.37E-17     -0.88 1.41E-02 -3.56 9.79E-11
NPR3 4883 0.59 1.68E-03 -3.49 4.34E-08 -1.03 1.59E-02 -1.30 2.70E-07 -4.77 5.00E-05 -0.98 2.75E-03 -2.09 1.22E-13 -4.50 5.93E-22
HAO2 51179 1.30 1.97E-08 -3.16 3.98E-08 -2.66 1.16E-05 -1.51 3.90E-06 -2.52 4.96E-09 -1.43 3.63E-04 -2.65 2.75E-13 -5.36 2.65E-18
IGF2BP3 10643 -1.17 2.29E-04 -5.91 1.85E-04     2.07 1.26E-08 2.92 4.97E-03 2.27 6.80E-07 2.75 2.42E-11 3.66 1.76E-14
NAT8 9027 0.93 4.85E-06   4.77E-21 -4.02 3.71E-12 -1.23 1.39E-05 -1.41   -1.05 6.89E-03 -1.65 4.74E-07 -4.03 2.49E-14
CXCL14 9547 0.55 4.45E-03 -5.22   -4.03 2.68E-14             -0.92 5.69E-03 -1.00 2.80E-02
TMEM27 57393 0.56 5.19E-04 -5.50 2.08E-29 -3.11 1.12E-13 -1.36 2.38E-10 -1.13 2.94E-03 -0.78 3.29E-02 -1.63 3.01E-08 -4.25 1.76E-18
GLB1L2 89944         -1.99 2.42E-13                    
SLC5A10 125206 1.05 1.06E-10 -2.20 9.53E-29 -5.16 6.28E-25 -1.18 1.81E-07 -1.74 2.60E-05 -1.10 9.80E-04 -1.94 2.93E-11 -4.35 1.27E-19
TMEM171 134285 0.79 2.02E-07 -2.19 6.53E-09 0.95 1.26E-03 -1.46 2.24E-12     -0.71 3.57E-02 -1.71 3.56E-10 -2.86 5.65E-12
ALDH1A1 216     -1.62 2.44E-12 -1.41 2.78E-06     -1.04 5.99E-04     -0.68 2.46E-03 -1.10 2.98E-04
CLCN5 1184 0.45 1.10E-04 -0.60 2.16E-09 -0.71 5.97E-03 -1.17 1.71E-14 -1.55 3.13E-08 -0.86 5.32E-06 -1.65 3.33E-22 -2.47 4.46E-22
ETFDH 2110 0.41 2.09E-08 -3.24 3.43E-04 0.99 1.23E-12 -0.49 6.63E-07 -0.61 3.52E-04 -0.45 2.97E-05 -0.83 4.72E-18 -1.32 2.34E-22
TADA2B 93624         0.66 7.28E-10 -0.28 2.34E-04     -0.25 1.25E-02 -0.25 2.12E-03 -0.35 1.51E-03
PDZK1 5174 0.56 1.12E-05 3.32 1.17E-22 -2.79 2.93E-17 -0.74 1.85E-05 -1.02 7.39E-04 -0.82 8.12E-05 -1.63 1.46E-18 -2.72 5.57E-22
FKBP9P1 360132 -0.60 2.36E-03 1.44 4.31E-31     1.14 1.35E-06 2.65 4.96E-17 1.72 5.35E-05 2.47 3.20E-11 3.51 5.37E-16
CYS1 192668 0.32 4.85E-02 -1.64 1.16E-07     -0.92 9.11E-06 -1.20 1.02E-03 -0.72 3.86E-02 -1.66 2.74E-09 -1.43 2.77E-04
GBA3 57733 0.59 2.05E-03   3.15E-04 -2.63 4.64E-08 -1.27 7.61E-07 -2.35 1.29E-06 -1.01 1.18E-03 -2.15 5.05E-15 -5.18 4.29E-28