Table 3. Results of differential expression analysis of T1 clusters with sufficient number of samples (Clusters 2 to 6) with cluster 1 (n = 103) as a reference and results of differential expression analysis of T3 clusters with sufficient number of members (Cluster 2 through 4), using Cluster 1 (n = 66) as a reference group.
Gene Symbol | Entrez | T1 | T3 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cluster 2 (n = 91) | Cluster 3 (n = 12) | Cluster 4 (n = 11) | Cluster 5 (n = 42) | Cluster 6 (n = 11) | Cluster 2 (n = 36) | Cluster 3 (n = 43) | Cluster 4 (n = 29) | ||||||||||
logFC | FDR | logFC | FDR | logFC | FDR | logFC | FDR | logFC | FDR | logFC | FDR | logFC | FDR | logFC | FDR | ||
A2 vs A1 | |||||||||||||||||
KIDINS220 | 57498 | -0.82 | 2.10E-05 | -0.27 | 1.53E-02 | -0.74 | 2.94E-07 | ||||||||||
MAP7 | 9053 | 0.52 | 1.36E-05 | -0.78 | 5.00E-03 | -0.79 | 3.56E-03 | -1.18 | 8.05E-14 | -2.16 | 1.37E-12 | -0.99 | 3.68E-05 | -1.71 | 3.26E-15 | -2.65 | 4.03E-16 |
IL6 | 3569 | -0.88 | 5.45E-03 | 1.65 | 3.36E-03 | -2.05 | 7.15E-03 | 3.17 | 3.06E-20 | 3.19 | 4.27E-11 | 1.80 | 9.49E-05 | 3.57 | 9.61E-19 | 4.07 | 1.89E-18 |
ATP6V1G1 | 9550 | 0.97 | 3.41E-18 | -0.20 | 1.78E-02 | -0.55 | 5.02E-05 | -0.24 | 7.85E-03 | ||||||||
BACH1 | 571 | -0.39 | 2.99E-05 | -0.68 | 7.90E-04 | 0.47 | 3.71E-05 | ||||||||||
RCAN1 | 1827 | 0.53 | 2.13E-03 | -1.44 | 3.20E-04 | -0.67 | 4.80E-03 | -1.17 | 4.15E-03 | -0.71 | 2.06E-02 | -1.08 | 1.79E-05 | -1.66 | 3.49E-06 | ||
PLPP3 | 8613 | -0.83 | 6.16E-04 | -0.65 | 7.16E-06 | -1.31 | 3.23E-07 | -0.73 | 1.25E-06 | -2.21 | 5.64E-23 | ||||||
TRMT10B | 158234 | -0.40 | 2.32E-03 | -0.80 | 3.27E-04 | -0.39 | 1.95E-02 | ||||||||||
FRMD3 | 257019 | -0.74 | 8.62E-03 | -1.66 | 6.82E-09 | -0.99 | 5.04E-10 | -2.85 | 4.06E-19 | -0.64 | 2.47E-03 | -1.12 | 2.63E-10 | -1.69 | 3.77E-11 | ||
MYOZ1 | 58529 | 0.97 | 1.48E-03 | -2.29 | 2.33E-08 | 0.56 | 2.37E-02 | ||||||||||
PTAR1 | 375743 | -0.49 | 3.95E-02 | -0.68 | 3.08E-07 | -1.50 | 6.71E-10 | -0.46 | 1.32E-03 | -0.66 | 7.06E-08 | -0.91 | 7.45E-08 | ||||
RUSC2 | 9853 | -0.97 | 3.65E-07 | -0.25 | 3.76E-02 | -1.19 | 2.20E-09 | -0.33 | 4.12E-02 | -0.37 | 4.66E-03 | ||||||
SHISA4 | 149345 | -0.35 | 1.84E-03 | 0.97 | 2.91E-06 | 0.44 | 4.96E-02 | 0.59 | 2.22E-05 | 0.92 | 1.60E-05 | 0.53 | 1.12E-02 | 0.77 | 4.53E-06 | 1.33 | 8.18E-11 |
A2 vs A3 | |||||||||||||||||
AOC1 | 26 | 0.66 | 1.90E-02 | -4.37 | 2.76E-08 | -0.95 | 1.40E-02 | 1.39 | 6.78E-03 | ||||||||
ACSM2B | 348158 | 1.10 | 5.32E-08 | -5.35 | 1.91E-18 | -3.27 | 3.15E-09 | -1.23 | 1.56E-05 | -1.03 | 3.76E-02 | -1.98 | 1.73E-10 | -3.85 | 7.20E-15 | ||
PAX2 | 5076 | 2.14 | -1.62 | 1.65E-07 | -0.77 | 1.13E-05 | 3.72E-45 | -1.02 | 1.26E-04 | -0.80 | 2.88E-02 | ||||||
PTPRH | 5794 | -1.06 | 6.86E-05 | -5.98 | 1.15E-06 | 3.32 | 1.70E-30 | 5.17 | 4.22E-05 | 1.49 | 3.69E-04 | 2.26 | 2.10E-10 | 4.57 | 6.27E-29 | ||
SLC22A2 | 6582 | -2.55 | 1.04E-23 | -3.40 | 1.04E-10 | -0.98 | 2.88E-04 | -2.02 | 1.37E-17 | -0.88 | 1.41E-02 | -3.56 | 9.79E-11 | ||||
NPR3 | 4883 | 0.59 | 1.68E-03 | -3.49 | 4.34E-08 | -1.03 | 1.59E-02 | -1.30 | 2.70E-07 | -4.77 | 5.00E-05 | -0.98 | 2.75E-03 | -2.09 | 1.22E-13 | -4.50 | 5.93E-22 |
HAO2 | 51179 | 1.30 | 1.97E-08 | -3.16 | 3.98E-08 | -2.66 | 1.16E-05 | -1.51 | 3.90E-06 | -2.52 | 4.96E-09 | -1.43 | 3.63E-04 | -2.65 | 2.75E-13 | -5.36 | 2.65E-18 |
IGF2BP3 | 10643 | -1.17 | 2.29E-04 | -5.91 | 1.85E-04 | 2.07 | 1.26E-08 | 2.92 | 4.97E-03 | 2.27 | 6.80E-07 | 2.75 | 2.42E-11 | 3.66 | 1.76E-14 | ||
NAT8 | 9027 | 0.93 | 4.85E-06 | 4.77E-21 | -4.02 | 3.71E-12 | -1.23 | 1.39E-05 | -1.41 | -1.05 | 6.89E-03 | -1.65 | 4.74E-07 | -4.03 | 2.49E-14 | ||
CXCL14 | 9547 | 0.55 | 4.45E-03 | -5.22 | -4.03 | 2.68E-14 | -0.92 | 5.69E-03 | -1.00 | 2.80E-02 | |||||||
TMEM27 | 57393 | 0.56 | 5.19E-04 | -5.50 | 2.08E-29 | -3.11 | 1.12E-13 | -1.36 | 2.38E-10 | -1.13 | 2.94E-03 | -0.78 | 3.29E-02 | -1.63 | 3.01E-08 | -4.25 | 1.76E-18 |
GLB1L2 | 89944 | -1.99 | 2.42E-13 | ||||||||||||||
SLC5A10 | 125206 | 1.05 | 1.06E-10 | -2.20 | 9.53E-29 | -5.16 | 6.28E-25 | -1.18 | 1.81E-07 | -1.74 | 2.60E-05 | -1.10 | 9.80E-04 | -1.94 | 2.93E-11 | -4.35 | 1.27E-19 |
TMEM171 | 134285 | 0.79 | 2.02E-07 | -2.19 | 6.53E-09 | 0.95 | 1.26E-03 | -1.46 | 2.24E-12 | -0.71 | 3.57E-02 | -1.71 | 3.56E-10 | -2.86 | 5.65E-12 | ||
ALDH1A1 | 216 | -1.62 | 2.44E-12 | -1.41 | 2.78E-06 | -1.04 | 5.99E-04 | -0.68 | 2.46E-03 | -1.10 | 2.98E-04 | ||||||
CLCN5 | 1184 | 0.45 | 1.10E-04 | -0.60 | 2.16E-09 | -0.71 | 5.97E-03 | -1.17 | 1.71E-14 | -1.55 | 3.13E-08 | -0.86 | 5.32E-06 | -1.65 | 3.33E-22 | -2.47 | 4.46E-22 |
ETFDH | 2110 | 0.41 | 2.09E-08 | -3.24 | 3.43E-04 | 0.99 | 1.23E-12 | -0.49 | 6.63E-07 | -0.61 | 3.52E-04 | -0.45 | 2.97E-05 | -0.83 | 4.72E-18 | -1.32 | 2.34E-22 |
TADA2B | 93624 | 0.66 | 7.28E-10 | -0.28 | 2.34E-04 | -0.25 | 1.25E-02 | -0.25 | 2.12E-03 | -0.35 | 1.51E-03 | ||||||
PDZK1 | 5174 | 0.56 | 1.12E-05 | 3.32 | 1.17E-22 | -2.79 | 2.93E-17 | -0.74 | 1.85E-05 | -1.02 | 7.39E-04 | -0.82 | 8.12E-05 | -1.63 | 1.46E-18 | -2.72 | 5.57E-22 |
FKBP9P1 | 360132 | -0.60 | 2.36E-03 | 1.44 | 4.31E-31 | 1.14 | 1.35E-06 | 2.65 | 4.96E-17 | 1.72 | 5.35E-05 | 2.47 | 3.20E-11 | 3.51 | 5.37E-16 | ||
CYS1 | 192668 | 0.32 | 4.85E-02 | -1.64 | 1.16E-07 | -0.92 | 9.11E-06 | -1.20 | 1.02E-03 | -0.72 | 3.86E-02 | -1.66 | 2.74E-09 | -1.43 | 2.77E-04 | ||
GBA3 | 57733 | 0.59 | 2.05E-03 | 3.15E-04 | -2.63 | 4.64E-08 | -1.27 | 7.61E-07 | -2.35 | 1.29E-06 | -1.01 | 1.18E-03 | -2.15 | 5.05E-15 | -5.18 | 4.29E-28 |