Skip to main content
. 2019 May 31;14(5):e0217095. doi: 10.1371/journal.pone.0217095

Fig 1. Effect of testosterone and flutamide on the embryo implantation and pregnancy.

Fig 1

(A) Schematic representation of experimental design. Female and male mice were mated, and day of finding vaginal plug was regarded as gestational day (GD) 1. Pregnant mice were administered with testosterone propionate or/and flutamide from GD 6 to GD 9. Finally, the experimental mice were euthanized before cervical dislocation for samples collection between 14:00-15:00 on GD 9. (B) Representative pictures of implanted embryos in uteri. (C) The numbers of implanted embryo. (D) The ratio of resorbed embryo/implanted embryo. (E) The ratio of uterus/body weight; Results are shown as the mean ± SD of 10 animals. Groups with different superscript letters are statistically different (P < 0.05). Con, Control group; L, 0.1 mg testosterone propionate (TP)/per mouse; L+F, 0.1 mg TP + 0.15 mg flutamide /per mouse; H, 1 mg TP /per mouse; H+F, 1 mg TP + 0.15 mg flutamide /per mouse.