Table 3. Expression of selected miRNAs expression in blood of BC patients at pre-RT control and post-RT depending on CVD-linked clinical parameters, received treatment and BC side.
| Pre-RT control | Post-RT |
|||||
|---|---|---|---|---|---|---|
| Dyslipidemia |
No (71.3%) |
Yes (27.2%) |
p value |
No (71.3%) |
Yes (27.2%) |
p value |
| miRNA-146a | 2.38±0.043 | 2.20±0.057 | 0.023 | 2.45±0.037 | 2.28±0.070 | 0.023 |
| miRNA-155 | 2.08±0.044 | 1.88±0.064 | 0.016 | 2.12±0.041 | 1.94±0.075 | 0.033 |
| miRNA-221 | 2.71±0.048 | 2.51±0.060 | 0.023 | 2.80±0.040 | 2.61±0.074 | 0.018 |
| miRNA-222 | 3.37±0.049 | 3.12±0.063 | 0.005 | 3.49±0.042 | 3.26±0.082 | 0.009 |
| Hypothyroidism |
No (91.2%) |
Yes (7.4%) |
p value |
No (91.2%) |
Yes (7.4%) |
p value |
| miRNA-146a | 2.35±0.037 | 2.06±0.1 | 0.026 | 2.43±0.034 | 2.15±0.144 | 0.028 |
| miRNA-155 | 2.05±0.039 | 1.76±0.10 | 0.036 | 2.07±0.037 | 1.80±0.141 | 0.034 |
| miRNA-221 | 2.68±0.041 | 2.38±0.10 | 0.450 | 2.77±0.036 | 2.45±0.146 | 0.017 |
| miRNA-222 | 3.33±0.042 | 2.96±0.10 | 0.015 | 3.46±0.039 | 3.07±0.173 | 0.009 |
| Chemotherapy |
No (39%) |
Yes (55.1%) |
p value |
No (39%) |
Yes (55.1%) |
p value |
| miRNA-146a | 2.20±0.053 | 2.42±0.047 | 0.003 | 2.34±0.045 | 2.45±0.050 | 0.119 |
| miRNA-155 | 1.86±0.054 | 2.14±0.048 | 0.000 | 1.97±0.053 | 2.15±0.051 | 0.025 |
| miRNA-221 | 2.46±0.056 | 2.78±0.050 | 0.000 | 2.65±0.053 | 2.81±0.050 | 0.030 |
| miRNA-222 | 3.13±0.055 | 3.41±0.055 | 0.001 | 3.34±0.055 | 3.49±0.055 | 0.069 |
|
Targeted therapy |
No (78.7%) |
Yes (17.6%) |
p value |
No (78.7%) |
Yes (17.6%) |
p value |
| miRNA-146a | 2.3±0.038 | 2.47±0.091 | 0.054 | 2.41±0.036 | 2.38±0.094 | 0.709 |
| miRNA-155 | 2.00±0.041 | 2.19±0.088 | 0.045 | 2.08±0.040 | 2.08±0.098 | 0.940 |
| miRNA-221 | 2.60±0.041 | 2.89±0.093 | 0.003 | 2.75±0.040 | 2.73±0.089 | 0.803 |
| miRNA-222 | 3.25±0.042 | 3.53±0.106 | 0.005 | 3.44±0.043 | 3.38±0.096 | 0.563 |
| BC side |
right (48.5%) |
left (50%) |
p value |
right (48.5%) |
left (50%) |
p value |
| miRNA-146a | 2.24±0.053 | 2.42±0.044 | 0.033 | 2.32±0.048 | 2.50±0.044 | 0.025 |
| miRNA-155 | 1.96±0.054 | 2.11±0.050 | 0.133 | 2.00±0.052 | 2.14±0.050 | 0.133 |
| miRNA-221 | 2.55±0.058 | 2.76±0.048 | 0.021 | 2.66±0.050 | 2.83±0.049 | 0.053 |
| miRNA-222 | 3.22±0.060 | 3.39±0.052 | 0.083 | 3.37±0.056 | 3.48±0.053 | 0.568 |
BC, breast cancer; RT, radiotherapy; miRNA, microRNA.
Mean ± SEM of the expression (log(2-DCt)+3) of selected miRNAs is shown. Statistics: Single factor ANOVA test. p value indicates differences between groups.