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. 2019 May;40(2):79–97. doi: 10.33176/AACB-18-00017

Figure 1.

Figure 1

Conceptual illustration of precision diagnostics and traditional diagnostics in recognition of kidney injury and disease. Individuals may have genetic susceptibility for kidney injury development during life. Molecular alterations may occur during aging and in response to interventions and these may be recognised by molecular profiling via omics (e.g. metabolomics, peptidomics and proteomics). Precision diagnostics includes the early and precise recognition of genetic susceptibility and molecular alterations. Traditional diagnostics typically recognises late stage kidney damage and decreased kidney function through functional markers, such as serum creatinine, cystatin C and eGFR.