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. 2019 May 31;14(5):e0217789. doi: 10.1371/journal.pone.0217789

Fig 1. Strictinin interacts with ROR1 in TNBC.

Fig 1

a) Homology Model of tROR1. Whereas N-terminus is indicated by a red ball, C-terminus is indicated by a blue ball. b, c) Strictinin docked to tROR1 and ligand interactions diagram. Whereas N-terminus is indicated by a red ball, C-terminus is indicated by a blue ball. d, e) Immunoblot and immunofluorescence investigating basal ROR1 expression in two TNBC lines and non-malignant breast epithelial line, MCF-10A. f) MTT assessing effect of ROR1 siRNA knockdown on strictinin cytotoxicity in TNBC. g) Immunoblot showing effect of siROR1 knockdown and strictinin on ROR1 expression in MDA-MB-231. h) Co-immunoprecipitation of ROR1 receptor showing inhibition of Wnt-5a binding to ROR1 after strictinin treatment. (* = p.value <0.05, n = 3).