Table 2. Differences between patients (PD) and healthy controls (HC).
| AD | MD | RD | ND | CI | |
|---|---|---|---|---|---|
| Brainstem | |||||
| PD/HC | - | - | - | - | 1.075* (PD: 0.17 ± 0.03) (HC: 0.16 ± 0.03) |
| AUC | 0.69 | ||||
| % | 21.60% | ||||
| Right thalamus | |||||
| PD/HC | 1.018 (PD: 1.35 ± 0.30) (HC: 1.33 ± 0.30) |
1.020 (PD: 1.18 ± 0.30) (HC: 1.16 ± 0.30) |
1.022 (PD: 1.17 ± 0.35) (HC: 1.14 ± 0.35) |
0.97* (PD: 0.62 ± 0.13) (HC: 0.63 ± 0.13) |
1.071 (PD: 0.12 ± 0.03 (HC: 0.11 ± 0.03) |
| AUC | 0.55 | 0.55 | 0.55 | 0.59 | 0.67 |
| % | 19.70% | 16.20% | 15.80% | 41.10% | 31.80% |
| Left thalamus | |||||
| PD/HC | - | - | - | 0.978* (PD: 0.69 ± 0.10) (HC: 0.70 ± 0.10) |
1.071 (PD: 0.12 ± 0.03) (HC:0.11 ± 0.03) |
| AUC | 0.59 | 0.67 | |||
| % | 30.90% | 27.40% | |||
| Right hippocampus | |||||
| PD/HC | 1.035 (PD: 1.35 ± 0.20) (HC: 1.31 ± 0.20) |
1.037 (PD: 1.16 ± 0.20) (HC: 1.11 ± 0.20) |
1.040 (PD: 1.05 ± 0.40) (HC: 1.01 ± 0.30) |
0.967* (PD: 0.58 ± 0.11) (HC: 0.60 ± 0.10) |
- |
| AUC | 0.55 | 0.54 | 0.54 | 0.55 | |
| % | 45.54% | 50.82% | 54.10% | 48.63% | |
| Left hippocampus | |||||
| PD/HC | 1.039 (PD: 1.33 ± 0.30) (HC: 1.28 ± 0.20) |
1.041 (PD: 1.14 ± 0.20) (HC: 1.09 ± 0.20) |
1.045 (PD: 1.05 ± 0.50) (HC: 1.00 ± 0.30) |
0.964 (PD: 0.57 ± 0.11) (HC: 0.59 ± 0.10) |
- |
| AUC | 0.54 | 0.54 | 0.53 | 0.55 | |
| % | 21.03% | 19.16% | 17.29% | 15.89% | |
| Right amygdala | |||||
| PD/HC | 1.022* (PD: 1.23 ± 0.20) (HC: 1.21± 0.20) |
1.022* (PD:1.03 ±0.20) (HC:1.01± 0.20) |
1.022* (PD:0.94 ± 0.40) (HC: 0.92± 0.40) |
0.973* (PD: 0.63 ± 0.14) (HC: 0.64 ± 0.13) |
1.084 (PD: 0.05 ± 0.001) (HC: 0.05 ± 0.01) |
| AUC | 0.55 | 0.55 | 0.55 | 0.57 | 0.66 |
| % | 47,37% | 52,63% | 50% | 88,60% | 17.54% |
| Left amygdala | |||||
| PD/HC | 1.025* (PD: 1.28 ± 0.20) (HC: 1.25 ± 0.20) |
1.029* (PD:1.04 ± 0.20) (HC: 1.01± 0.20) |
1.034* (PD: 0.85 ± 0.40) (HC: 0.92 ± 0.40) |
0.975* (PD:0.60 ± 0.09) (HC:0.61 ± 0.09) |
- |
| AUC | 0.58 | 0.59 | 0.60 | 0.57 | |
| % | 82.11% | 89.47% | 86.32% | 37.89% | |
The results of the voxel wise analysis, showing relative group difference (PC/HC), along with mean absolute value for each group, measured separability (AUC) and the percentage of significant voxels (p<0.05) compared to the full ROI size for each ROI and diffusion metric.
‘-‘ denotes when there is no significant group difference.
‘*’ denotes parameters that were significant when accounting for multiple comparisons (p<0.001). The DTI-metrics are in the unit 10-3mm2/s while the RSI-metrics are unitless.