Fig 2. Assessment of yeast interfering RNA larvicide syt.427 activity in A. aegypti.

A. Consumption of inactivated dried yeast interfering RNA syt.427 larvicide tablets induced larval mortality in the L4 larval or pupal stages (days 4–8; compare to larvae fed with control yeast interfering RNA that survived and pupariated). B. Dose-response curves depicting the mass of syt.427 vs. the percentage of A. aegypti larval mortality are shown. LD₅₀ values for syt.427 with upper and lower confidence limits (CL) are indicated. Regression analysis demonstrated that the dose-response data were linearly correlated (R² = 0.9365). Additional details regarding calculation of lethal doses are provided in the methods section.