Table 4. Model details including chemotherapeutic agents, route of administration, median cumulative dose, and upper and lower quartiles (data set 1a).
Animal | Type | Chemotherapeutic agent | Route of administration | Median | Q1 | Q3 |
---|---|---|---|---|---|---|
Mouse | Hydroxamate histone deacetylase inhibitors | JNJ-26481585 | Subcutaneous | 32.5 | 23.75 | 41.25 |
Other | Salinomycin | Intraperitoneal | 140 | 140 | 140 | |
Platinum compounds | Cisplatin | Hindpaw | 0.004 | 0.002 | 0.022 | |
Intraperitoneal | 20.5 | 8.25 | 23 | |||
Subcutaneous | 0.15 | 0.15 | 0.15 | |||
Oxaliplatin | Hindpaw | 0.04 | 0.04 | 0.04 | ||
Intraperitoneal | 10 | 3 | 30 | |||
Intravenous | 23 | 13.5 | 31 | |||
Subcutaneous | 0.04 | 0.04 | 0.04 | |||
Proteasome inhibitors | Bortezomib | Intraperitoneal | 0.75 | 0.425 | 1.95 | |
Intravenous | 6.4 | 6.4 | 6.4 | |||
Subcutaneous | 12 | 12 | 18 | |||
Taxanes | Paclitaxel | Intraperitoneal | 10 | 5 | 16 | |
Intravenous | 190 | 165 | 230 | |||
Subcutaneous | 10 | 10 | 10 | |||
Tail vein | 75 | 75 | 75 | |||
Vinca alkaloids | Vincristine | Intraperitoneal | 0.7 | 0.2 | 3.9 | |
Rat | Binding of growth factor inhibitors | Suramin | Intravenous | 25 | 17.5 | 37.5 |
Other | Methotrexate | Subcutaneous | 3.75 | 3.75 | 3.75 | |
Platinum compounds | Carboplatin | Intraperitoneal | 112.5 | 101.25 | 123.75 | |
Cisplatin | Intraperitoneal | 10 | 5 | 15 | ||
Intravenous | 2 | 2 | 2 | |||
Subcutaneous | 8 | 8 | 8 | |||
Oxaliplatin | Intraperitoneal | 16 | 8 | 32 | ||
Intravenous | 2 | 2 | 8 | |||
Proteasome inhibitors | Bortezomib | Intraperitoneal | 0.7 | 0.6 | 1 | |
Intravenous | 4.8 | 4.2 | 4.8 | |||
Taxanes | Docetaxel | Intravenous | 25 | 17.5 | 32.5 | |
Tail vein | 10 | 10 | 10 | |||
Paclitaxel | Intraperitoneal | 8 | 7.25 | 8.5 | ||
Intravenous | 24.5 | 9.75 | 33.25 | |||
Tail vein | 8 | 8 | 8 | |||
Intrathecala | 6 | 3.1 | 13 | |||
Nanoparticle albumin-bound paclitaxel | Intravenous | 26.8 | 25.4 | 28.2 | ||
Vinca alkaloids | Vincristine | Intraperitoneal | 0.95 | 0.5 | 1 | |
Intravenous | 0.435 | 0.2125 | 0.75 | |||
Subcutaneous | 0.42 | 0.42 | 0.42 | |||
Tail | 0.625 | 0.5625 | 0.6875 |
a Drug doses are shown in mg/kg, except intrathecal paclitaxel, shown in ng.