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. 2019 May 20;17(5):e3000243. doi: 10.1371/journal.pbio.3000243

Table 4. Model details including chemotherapeutic agents, route of administration, median cumulative dose, and upper and lower quartiles (data set 1a).

Animal Type Chemotherapeutic agent Route of administration Median Q1 Q3
Mouse Hydroxamate histone deacetylase inhibitors JNJ-26481585 Subcutaneous 32.5 23.75 41.25
Other Salinomycin Intraperitoneal 140 140 140
Platinum compounds Cisplatin Hindpaw 0.004 0.002 0.022
Intraperitoneal 20.5 8.25 23
Subcutaneous 0.15 0.15 0.15
Oxaliplatin Hindpaw 0.04 0.04 0.04
Intraperitoneal 10 3 30
Intravenous 23 13.5 31
Subcutaneous 0.04 0.04 0.04
Proteasome inhibitors Bortezomib Intraperitoneal 0.75 0.425 1.95
Intravenous 6.4 6.4 6.4
Subcutaneous 12 12 18
Taxanes Paclitaxel Intraperitoneal 10 5 16
Intravenous 190 165 230
Subcutaneous 10 10 10
Tail vein 75 75 75
Vinca alkaloids Vincristine Intraperitoneal 0.7 0.2 3.9
Rat Binding of growth factor inhibitors Suramin Intravenous 25 17.5 37.5
Other Methotrexate Subcutaneous 3.75 3.75 3.75
Platinum compounds Carboplatin Intraperitoneal 112.5 101.25 123.75
Cisplatin Intraperitoneal 10 5 15
Intravenous 2 2 2
Subcutaneous 8 8 8
Oxaliplatin Intraperitoneal 16 8 32
Intravenous 2 2 8
Proteasome inhibitors Bortezomib Intraperitoneal 0.7 0.6 1
Intravenous 4.8 4.2 4.8
Taxanes Docetaxel Intravenous 25 17.5 32.5
Tail vein 10 10 10
Paclitaxel Intraperitoneal 8 7.25 8.5
Intravenous 24.5 9.75 33.25
Tail vein 8 8 8
Intrathecala 6 3.1 13
Nanoparticle albumin-bound paclitaxel Intravenous 26.8 25.4 28.2
Vinca alkaloids Vincristine Intraperitoneal 0.95 0.5 1
Intravenous 0.435 0.2125 0.75
Subcutaneous 0.42 0.42 0.42
Tail 0.625 0.5625 0.6875

a Drug doses are shown in mg/kg, except intrathecal paclitaxel, shown in ng.