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. 2019 May 13;15(5):e1007755. doi: 10.1371/journal.ppat.1007755

Fig 3. Requirement of a helicase-active E1 for genome amplification but not maintenance.

Fig 3

(A) The virus genome copy number per cell of E1-defective HPV11 (HPV11E1def, upper) and HPV16 (HPV16E1def, lower) transfected NIKS was measured, and prepared for presentation as outlined in Fig 1E. (B) The virus genome copy number per cell of E1 helicase-defective HPV11 (HPV11E1K484A left) or HPV16 (HPV16E1K483A, right) transfected into NIKS was measured and prepared for presentation as outlined in Fig 1E. Both the HPV11 E1K484A and HPV16 E1K483A genome declined post-confluence in the absence of a helicase-active E1 gene.