Fig 4. Advanced versus mild glaucomatous optic nerve (ON) tract profiles.

Average tract profiles for the ONs of 6 eyes with advanced (red) and 6 eyes with mild (blue) glaucoma, with the middle 80% of samples marked with bold lines, and each 10% bin marked with dotted lines. Significant differences (FDR < 0.05) denoted by *. (A) Differences in fractional anisotropy across the middle 80% of samples (p = 2.19e-5, FDR = 4.0e-4), and in 3/8 individual bins (p₁ = 2.20e-5, FDR₁ = 4.0e-4; p₂ = 0.0016, FDR₂ = 0.019; p₃ = 0.0072, FDR₃ = 0.048). (B) Difference in mean diffusivity in 1/8 bins (p = 0.0080, FDR = 0.048). (C) Differences in radial diffusivity in 1/8 individual bins (p = 0.0026, FDR = 0.023). (D) Difference in axial diffusivity was not significant (all FDR > 0.05).