Fig 4. Association of right-sided primary tumour location with overall survival (meta-analysis).
Meta-analysis of published studies including own data (Heterogeneity: I2 = 50.8% / p = 0.0216). (A) Forrest plot: right-sided primary tumour location is significantly associated with worse overall survival after resection for liver metastases (random effects model: p<0.001) (B) Funnel plot analysis does not indicate a relevant publication bias but minor small trial bias: While the number of larger studies (tip of the pyramid) on both sides of the total effects line are evenly distributed, two smaller studies with an overestimating positive effect have only one negative study as counterparts (base of the pyramid). CI = confidence interval; HR = hazard ratio; KRASmut/wt = KRAS mutated or wild-type subgroup; with or w/o CTX = with or without preoperative chemotherapy.