Fig 5. Association of right-sided primary tumour location with disease-free survival (meta-analysis).
Meta-analysis of published studies including own data (Heterogeneity: I2 = 72.4% / p<0.001). (A) Forrest plot: right-sided primary tumour location is associated with worse disease-free survival after resection for liver metastases, however not significant in the random effects model (p = 0.077). (B) Funnel plot analysis does indicate only a minimal publication bias with two large study outliers outside the 95%CI (at the tip of the pyramid) but no small trial bias (two smaller studies on the left side of the overall effects line have larger counterparts on the right side). CI = confidence interval; HR = hazard ratio; KRASmut/wt = KRAS mutated or wild-type subgroup; with / w/o CTX = with or without preoperative chemotherapy.