Table 1. Characteristics of 725 patients cohort and individuals with low and high oxLDL levels.
| Parameter | Total cohort, n = 725 | Low oxLDL levels group, n = 48 | High oxLDL levels group, n = 48 | P-value* |
|---|---|---|---|---|
| Age, years | 57 (51-63) | 59 (50-64) | 56 (51-62) | 0.703 |
| Men, n (%) | 206 (28.4) | 21 (43.8) | 17 (35.4) | 0.531 |
| Smoking, n (%) | 108 (14.9) | 7 (14.6) | 12 (25.0) | 0.306 |
| BMI, kg/m2 | 28.7 (25.8-32.2) | 28.7 (24.9-31.2) | 28.3 (26.1-32.0) | 0.613 |
| Waist, cm | 93 (84-102) | 94 (84-101) | 90 (85-102) | 0.946 |
| Total cholesterol, mmol/l | 5.90 (5.17-6.88) | 4.25 (3.90-4.88) | 7.66 (7.01-8.25) | 1.17 × 10−14 |
| Triglycerides, mmol/l | 1.60 (1.14-2.19) | 1.22 (0.84-1.71) | 2.20 (1.67-2.91) | 1.55 × 10−7 |
| LDL, mmol/l | 3.60 (2.92-4.39) | 2.31 (1.90-2.60) | 4.86 (3.93-5.61) | 2.04 × 10−14 |
| HDL, mmol/l | 1.34 (1.14-1.58) | 1.29 (1.10-1.50) | 1.20 (1.06-1.48) | 0.322 |
| Apolipoprotein B, mg/dl | 102 (87-123) | 72 (64-80) | 142 (125-154) | 7.88 × 10−14 |
| Apolipoprotein A1, mg/dl | 162 (144-184) | 151 (139-176) | 161 (141-181) | 0.347 |
| Lipoprotein (a), mg/dl | 11.4 (5.2-33.5) | 8.1 (3.4-22.8) | 13.4 (6.2-33.4) | 0.078 |
| oxLDL, U/dl | 68.50 (55.72-85.64) | 35.29 (31.02-39.64) | 118.35 (113.47-124.12) | 3.15 × 10−17 |
| oxLDL/LDL, U/dl per mmol per l | 19.32 (16.21-23.00) | 15.75 (12.64-18.53) | 23.79 (20.87-28.00) | 8.49 × 10−13 |
| oxLDL/ApoB, U/dl per mg per dl | 0.67 (0.56-0.78) | 0.48 (0.42-0.55) | 0.82 (0.75-1.01) | 4.05 × 10−15 |
| CRP, mg/dl | 0.24 (0.13-0.42) | 0.19 (0.09-0.37) | 0.28 (0.16-0.45) | 0.031 |
| Hypertension, n (%) | 586 (80.8) | 39 (81.3) | 37 (77.1) | 0.802 |
| Myocardial infarction, n (%) | 71 (9.8) | 7 (14.6) | 7 (14.6) | 0.772 |
| Diabetes mellitus, n (%) | 113 (15.6) | 9 (18.8) | 6 (12.5) | 0.544 |
| Stroke, n (%) | 16 (2.2) | 3 (6.3) | 4 (8.3) | 1.000 |
| Statins, n (%) | 163 (22.5) | 19 (39.6) | 13 (27.1) | 0.279 |
| Total stenosis, % | 80 (25-130) | 63 (23-115) | 75 (25-150) | 0.362 |
| Plaque number | 3 (1-4) | 2 (1-4) | 3 (1-5) | 0.315 |
| Mean-IMT, mm | 0.71 (0.62-0.85) | 0.71 (0.63-0.85) | 0.71 (0.61-0.86) | 0.916 |
BMI—body mass index, LDL—low-density lipoprotein, HDL—high-density lipoprotein, CRP—high-sensitivity C-reactive protein, oxLDL—oxidatively modified low-density lipoprotein, ApoB—Apolipoprotein B, Mean-IMT—mean intima-medial thickness. Data are presented as numbers (percentages) in cases of categorical data and median (25th–75th percentile) in cases of continuous data.
* P-value (difference between low and high oxLDL levels groups) for quantitative parameters was calculated for non-parametric Mann-Whitney test, for quality parameters P-value was calculated using two-tailed Fisher’s exact test if it is available, otherwise—for Yates’ corrected χ2 test.