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. Author manuscript; available in PMC: 2020 May 8.
Published in final edited form as: Cell Host Microbe. 2019 May 8;25(5):668–680.e7. doi: 10.1016/j.chom.2019.04.002

Figure 5: Lipidomic analysis reveals expansive shifts and insight into the bacterial lipid content dependent on serine palmitoyltransferase in the intestine.

Figure 5:

(A) The top 50 annotated metabolite features by FDR changed in BTWT- and BTΔSPT-colonized mice, clustered using Euclidean distance and Pearson correlation. The most abundant and changed features in BTWT-colonized mice were (B) CerPE and (C) DHCer. Their relative abundances in mouse caecum and culture are compared to those in BTΔSPT-colonized mouse caecum and culture, where they are not detected. The most abundant and changed features in BTΔSPT-colonized mice were (D) PE 32:0 and (E) PE 35:0. Their relative abundances in mouse caecum and culture are compared to those in BTΔWT-colonized mouse caecum and culture, where they are significantly decreased. Statistical analysis was performed using the Mann-Whitney U-test. ***p<0.001; **p<0.01; *p<0.05. Error bars are +/− SEM. See also Table S2 and Data Files S3 and S4.