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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Exp Neurol. 2019 Apr 10;316:39–51. doi: 10.1016/j.expneurol.2019.04.004

Figure 3. Neurodegeneration in the cortex following clodronate-induced microglia depletion.

Figure 3.

Representative photomicrographs of FJB-labeling in sham-injured (A-C) and brain-injured (D-F) animals injected with empty liposomes and sham-injured (G-I) and brain-injured (J-L) animals injected with clodronate liposomes at 3 (A,D,G,J), 15 (B,E,H,K), and 35 (C,F,I,L) days post-injury. (M) Quantification of FJB(+) profiles. Multivariate analysis of variance revealed that injury status, irrespective of treatment and time, was significant (p < 0.0001), and interaction between injury and treatment was significant at all time points (p < 0.0001); detailed statistical descriptions are provided in the Results. Bar graphs represent group means and error bars represent the standard error of the mean. Scale bar in L = 100μm for all panels.