Table 1. Neurologic outcomes following TBI in the neonate.
Animals in the 15-day and 35-day survival groups were tested for spatial learning on days 10-14 and 28-32 respectively and euthanized for histology. Animals in the 28-day survival group underwent testing in the straight path swim test on days 26-27 post-injury and euthanized for electrophysiology. Values represent means ± standard error of the mean. NA, not applicable; ND, not determined.
| Group | Time point (days) |
N (F, M) | Weight (g) | Apnea (s) | Righting reflex (s) |
|---|---|---|---|---|---|
| Sham Empty | 3 | 3 (1, 2) | 23.6 ± 1.3 | NA | ND |
| Sham Clodronate | 3 (1, 2) | 22.5 ± 1.0 | NA | ND | |
| Injured Empty | 5 (2, 3) | 21.2 ± 0.9 | 11 ± 4 | 207 ± 36 | |
| Injured Clodronate | 6 (1, 5) | 19.9 ± 0.5 | 18 ± 2 | 196 ± 42 | |
| Sham Empty | 15 | 5 (2, 3) | 22.7 ± 0.6 | NA | 56 ± 13 |
| Sham Clodronate | 5 (2, 3) | 23.6 ± 0.5 | NA | 59 ± 6 | |
| Injured Empty | 5 (3, 2) | 23.0 ± 0.2 | 13 ± 2 | 199 ± 33 | |
| Injured Clodronate | 5 (2, 3) | 23.3 ± 0.5 | 15 ± 3 | 163 ± 27 | |
| Sham Empty | 35 | 5 (2, 3) | 23.6 ± 0.6 | NA | 72 ± 4 |
| Sham Clodronate | 6 (2, 4) | 23.3± 1.3 | NA | 69 ± 13 | |
| Injured Empty | 5 (2, 3) | 24.2 ± 0.4 | 13 ± 1 | 156 ± 31 | |
| Injured Clodronate | 5 (2, 3) | 24.2 ± 0.9 | 18 ± 2 | 191 ± 29 | |
| Sham Empty | 28 | 9 (5, 4) | 22.8 ± 1.0 | NA | 107 ± 12 |
| Sham Clodronate | 9 (5, 4) | 22.1 ± 1.2 | NA | 101 ± 11 | |
| Injured Empty | 8 (4, 4) | 24.0 ± 0.7 | 15 ± 1 | 183 ± 21 | |
| Injured Clodronate | 9 (4, 5) | 22.1 ± 0.9 | 17 ± 1 | 230 ± 28 | |