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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Exp Neurol. 2019 Mar 23;317:244–259. doi: 10.1016/j.expneurol.2019.03.013

Fig. 1.

Fig. 1.

Study design. (A) The pups were returned to the dams for 1.5 to 3 h after right common carotid artery ligation. Thereafter, the pups were exposed to 8% oxygen with balanced nitrogen for 90 min at a constant temperature of 36°C. Thirty mg/kg of human blood-derived IAIPs or placebo were given intraperitoneally (I.P.) immediately, 24 and 48 h after termination of hypoxia. Body weight was measured immediately, 24, 48 and 72 h after hypoxia. Seventy-two h after hypoxia, a necropsy was performed and brain weight obtained. (B) Study design for delayed treatment. The procedures were the same as for the study design in A except that IAIPs or placebo were given 6, 24 and 48 h after the termination of hypoxia. Body weight was measured immediately, 6, 24, 48 and 72 h after hypoxia. Seventy-two h after hypoxia, an necropsy was performed and brain weight obtained. IAIP = Inter-Alpha Inhibitor proteins, PBS = phosphate buffered saline.