Table 2.

Heatmap of the inferred activity changes following training. The three study groups are in rows: Control group, COPD patients with normal BMI (COPD_{BMI_N}) and with low BMI (COPD_{BMI_L}). Columns represent the genes considered in our analysis, grouped by pathways or cellular function: ETC (electronic transport chain), TCA cycle (tricarboxylic acid cycle), Glycolysis, ROS (reactive-oxygen species metabolism), Transc. Reg. (transcriptional regulation), Cancer Met. (cancer metabolism), Transport, Lipid Met (lipid metabolism). Cell Cycle and Prot. Deg. (protein degradation). Adaptation to training is represented using the following code: i) red: decrease in the discrete value of the node in response to training and ii) green: increment in the discrete value of the node in response to training. In both cases, the intensity of the colors indicates: i) predicted response to training supported by between 67 and 99% of the models are highlighted with the lightest colors, ii) predictions supported by the 100% of the models are highlighted with medium intensity color and iii) darkest color indicates nodes with no adaptation to training (supported by the 100% of the models). Finally, results supported by experi-mental evidences that were integrated as constraints in our analysis, are labeled with an asterisk (*).

ETC

TCA cycle

Glycolysis

ROS

Transc. Reg.

Cancer Mat.

Transport

Lipid Met.

Cell Cycle

Prot. Deg.

ros

atp5d

cox6a2

ndufsl

ndufv 1

ndufs7

ndufb7

uqcrc1

ckmt2

cs

idh2

ogdh

suclgl

pkm2

pdha 1

pdk4

gpd2

gpdl

sod2

glrx

insr

mapk12

nol3

ppp2ca

srekl

hspb7

mcd30

crebl

parpl

flna

akpl

prkce

hsp9()ab

tnf

tp53

rtn4ipl

lin9

myb

myc

mll

stx4

P2ry2

trakl

tspo

pam 16

acbd3

col4a3bp

acadvl

fasn

gpam

PParg

inha

acsl5

casp8

cdk4

app

fastk

eln

ubc

Adaptation of training

Control

*

*

*

*

*

*

*

*

*

*

*

*

*

*

COPDBMI_N

*

*

*

*

*

COPDBMI_L

*

*

*

*

*

*

*

*

*