a, Total cellular and OL densities in Ctr WM, NAWM and MS lesions (data displayed as mean ± SEM, n=5 Ctr individuals, n=9 MS individuals, ANOVA). b, SOX6-expressing OPCs in Ctr WM, NAWM and MS lesions (scale bars 50µm, data displayed as mean ± SEM, n=4 Ctr individuals, n=5 MS individuals, ANOVA) and tSNE overlay of SOX6 expression in the Ctr and MS snRNA-seq dataset. c, OPALIN-expressing OL in Ctr WM, NAWM and MS lesions (scale bar: 50µm, data displayed as mean±SEM, n=3 Ctr individuals, n=5 MS individuals, ANOVA) and tSNE overlay of OPALIN expression in the Ctr and MS snRNA-seq dataset. d, CD74 expression in the Ctr and the MS snRNA-seq dataset and BaseScope in-situ validation of presence of CD74 combined with IHC staining for Olig1/2+ OLs (n=2 different MS patients, experiments were performed in 2 independent batches). e, Heatmap representing the average gene expression of a subset of genes, including myelin-related genes, in mature OL in Ctr vs. MS samples). For tSNEs and heatmap, n=4037 OL in Ctr and n=4737 OL in MS for all t-SNE projections). a-c: only p-values compared to Ctr are displayed.