| 1 Efficacy ‐ response (continuous): change in CGI score from baseline to end of study |
2 |
41 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.41 [‐1.46, 0.65] |
| 2 Efficacy ‐ response (continuous): change in CGI score from baseline to end of study [double blind only] |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 3 Change in mania rating from baseline to end of trial |
1 |
30 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.70 [‐9.12, 5.72] |
| 4 Change in BPRS from baseline to end of trial |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 4.1 Day 3 |
1 |
30 |
Mean Difference (IV, Fixed, 95% CI) |
‐4.4 [‐10.10, 1.30] |
| 4.2 Day 28 |
1 |
30 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.52 [‐6.68, 3.64] |
| 5 Change in IMPS from baseline to end of trial |
1 |
55 |
Mean Difference (IV, Random, 95% CI) |
0.66 [‐0.10, 1.42] |
| 5.1 Motor activity |
1 |
11 |
Mean Difference (IV, Random, 95% CI) |
1.00 [‐0.42, 2.42] |
| 5.2 Elevated mood |
1 |
11 |
Mean Difference (IV, Random, 95% CI) |
‐0.10 [‐1.96, 1.76] |
| 5.3 Pressure of speech |
1 |
11 |
Mean Difference (IV, Random, 95% CI) |
0.60 [‐1.10, 2.30] |
| 5.4 Logorrhoea |
1 |
11 |
Mean Difference (IV, Random, 95% CI) |
0.70 [‐0.98, 2.38] |
| 5.5 Insight |
1 |
11 |
Mean Difference (IV, Random, 95% CI) |
0.90 [‐1.11, 2.91] |
| 6 Change in GAF from baseline to end of trial |
1 |
30 |
Mean Difference (IV, Fixed, 95% CI) |
‐10.29 [‐26.28, 5.70] |
| 7 Simpson Angus scale change from baseline to end of trial |
1 |
30 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.17 [‐0.83, 0.49] |
| 8 Use of rescue medications (haloperidol) |
1 |
11 |
Odds Ratio (M‐H, Fixed, 95% CI) |
4.0 [0.27, 60.32] |
