Comparison 18. Appendix 3: lithium vs quetiapine ‐ single trial data and less common adverse events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Clinically significant increases in TSH	1	186	Odds Ratio (M‐H, Fixed, 95% CI)	17.92 [2.30, 139.36]
2 Dry mouth	1	205	Odds Ratio (M‐H, Fixed, 95% CI)	0.20 [0.08, 0.52]
3 Somnolence	1	205	Odds Ratio (M‐H, Fixed, 95% CI)	0.41 [0.18, 0.95]
4 Akathisia	1	205	Odds Ratio (M‐H, Fixed, 95% CI)	3.35 [0.34, 32.73]
5 Insomnia	1	205	Odds Ratio (M‐H, Fixed, 95% CI)	1.89 [0.81, 4.40]
6 URTI	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	1.01 [0.28, 3.65]
7 Headache	1	205	Odds Ratio (M‐H, Fixed, 95% CI)	1.73 [0.67, 4.42]
8 EPS	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	1.28 [0.33, 4.98]
9 ECG changes	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	1.28 [0.50, 3.28]
10 Asthenia	1	205	Odds Ratio (M‐H, Fixed, 95% CI)	0.61 [0.17, 2.14]
11 Constipation	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	0.28 [0.13, 0.63]
12 Depression	2	360	Odds Ratio (M‐H, Fixed, 95% CI)	0.40 [0.09, 1.76]
13 Cardiac disorders	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	0.25 [0.07, 0.92]
14 Weight loss	1	205	Odds Ratio (M‐H, Fixed, 95% CI)	3.42 [0.67, 17.38]
15 Anorexia	1	205	Odds Ratio (M‐H, Fixed, 95% CI)	10.72 [1.33, 86.24]
16 Bone marrow depression	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	3.08 [0.12, 76.74]
17 Nausea	1	205	Odds Ratio (M‐H, Fixed, 95% CI)	6.91 [0.82, 58.48]
18 Raised neutrophils > 10x109 /L	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	9.61 [0.51, 181.64]
19 Deranged LFTs > 3x normal range	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	0.39 [0.07, 2.07]
20 Vomiting	1	205	Odds Ratio (M‐H, Fixed, 95% CI)	6.91 [0.82, 58.48]
21 High blood glucose	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	1.01 [0.20, 5.18]
22 Hyperprolactinaemia > 20mcg for men and > 30mcg in women	1	108	Odds Ratio (M‐H, Fixed, 95% CI)	1.14 [0.36, 3.65]
23 GI disorder	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	0.70 [0.37, 1.34]
24 Nervous system disorders	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	0.86 [0.39, 1.91]
25 Infections and infestations	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	1.44 [0.63, 3.29]
26 Tremor	1	205	Odds Ratio (M‐H, Fixed, 95% CI)	3.79 [1.44, 9.99]
27 Respiratory, thoracic and mediastinal disorders	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	0.19 [0.02, 1.68]
28 Skin and subcutaneous tissue disorders	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	1.01 [0.28, 3.65]
29 Eye disorders	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	0.33 [0.03, 3.23]
30 Psychiatric disorders	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	1.74 [0.40, 7.53]
31 Metabolism and nutritional disorders	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	1.54 [0.25, 9.49]
32 MSK and connective tissue disorders	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	1.01 [0.14, 7.38]
33 Renal and urinary disorders	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	0.20 [0.01, 4.18]
34 Reproductive system and breast disorders	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	0.20 [0.01, 4.18]
35 Vascular disorders	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	0.5 [0.04, 5.63]
36 Blood and lymphatic disorders	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	5.20 [0.25, 110.07]
37 Hepatobiliary disorders	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	3.08 [0.12, 76.74]
38 Injury, poisoning and procedural complications	1	155	Odds Ratio (M‐H, Fixed, 95% CI)	3.08 [0.12, 76.74]
39 Weight gain	2	360	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]